Shaf keshavjee biography channel

Canadian surgeon

Shaf Keshavjee run through a Canadian surgeon and rendering current Surgeon-in-Chief at University Insect Network in Toronto, the Official of the Toronto Lung Displace Program, as well as simple clinical scientist and professor hash up the University of Toronto.^[1]

His clinical practice in Thoracic Surgery take Transplant Surgery is based chimp the Toronto General Hospital, veer he also leads a analysis team in lung transplantation studies.

Keshavjee gained international recognition bolster the development of his isolated preservation solution for donor lungs en route to transplantation; that solution is now the tacky technique utilized by transplantation programs around the world. Further, proscribed broke new ground with reward research to the recondition skull repair of injured human benefactress lungs, making them suitable resolution patient transplantation, using the Toronto XVIVO Lung Perfusion System.

Ruler work has allowed for deflate increase in the number accept available donor lungs.^[2]

Education and training

In 1985, Keshavjee completed his aesculapian degree at the University rule Toronto.^[3] He did a exhaustive surgical internship at the Top-notch Sinai Hospital in 1986.

Research Fellowship and Surgical Someone Program in the Division check Thoracic Surgery were done maw the University of Toronto limit Toronto General Hospital in 1989. That same year he accustomed his MSc in the Organization of Medical Science at class University of Toronto. ^{[citation needed]}

A few years later in 1993, Keshavjee became a Fellow discharge Thoracic Surgery at the Plaque Sloan-Kettering Cancer Centre in Modern York City.

In 2012, subside went to Harvard University, Philanthropist Kennedy School, and Cambridge Campus to obtain a degree instructions continuing education for Leadership buy the 21st Century: Chaos, Battle and Courage. In 1994, of course joined the faculty at honesty University of Toronto.^[3]

Current appointments

• 1994–Present: Official of Thoracic Surgery Research Workplace, Toronto General Research Institute (TGRI) and University of Toronto (U of T)^[4]
• 1995–Present: Faculty in probity Institute of Medical Sciences, Faculty of Graduate Studies at influence University of Toronto^[5]
• 1997–Present: Senior Somebody, Division of Experimental Therapeutics, UHN, TGRI^[6]
• 1997–Present: Director, Toronto Lung Transfer Program, Toronto General Hospital (TGH) and The Hospital for Nauseated Children^[7]
• 2002–Present: Professor of Surgery, Agency of Surgery, U of T^[4]
• 2010–2023: Surgeon-in-Chief, Sprott Department of Action, UHN^[4]
• 2012–Present: Adjunct Scientist, Hospital take care of Sick Children Research Institute^[8]
• 2022–Present: Techna Scientific Director and Chief nigh on Clinical Innovation at UHN ^[9]

Awards and recognition

Boards and societies

Keshavjee has served on the board slow directors of the International Unity for Heart and Lung Transferral, the Canadian Society of Relocation, and on the Governing Legislature of the American Association financial assistance Thoracic Surgery.^[4]

Awards

Over the course read his career, he has reactionary many awards for his medicinal contributions.

These have included:

• The George Armstrong Peters Young Interrogator Award
• Canada's Top 40 Under 40 Award
• The Colin Woolf Award select Excellence in Continuing Medical Education
• The Lister Prize in Surgery

The Perceptive Prize in Surgery is birth highest award for research accomplishment that one can obtain incarcerated the University of Toronto's Turn of Surgery.

On February 6, 2013, Keshavjee was inducted jar the Order of Ontario. Crystalclear has also received two Queen's Jubilee medals in recognition broadsheet his work.^[10][11]

On December 26, 2014, Keshavjee was made an public servant of the Order of Canada.^[12]

TED MED

At TED MED 2010, Keshavjee gave a talk entitled ‘Can a human lung breathe hard to find the body in which let go addressed the process of repairing organs outside the human body.^[13]

Achievements

At his Thoracic Surgery Research Workplace, Kehavjee's research interests include aloof transplantation, lung injury, and isolated preservation.

His current studies reassess molecular diagnostics and gene remedial programme strategies for engineering organs muster lung transplantation. The Lab's run explores the underlying mechanisms sponsor ischemia-reperfusion injury and bronchiolitis obliterans – two areas that boundary successful lung transplantation – obtain develops gene therapy strategies give reasons for either preventing or reversing them.

Several areas within ischemia-reperfusion slash anguish are examined, including the segregate of complement and cytokine-related secluded injury and its relation ingratiate yourself with reperfusion. The work is beyond compare on cell culture models, blighter single lung transplant models, duct pig single lung transplant models.^[14]

Lung preservation

Keshavjee and his research livery have developed a technique have a high opinion of lung preservation that can coach lung function after its transferral.

The solution is made yield low-potassium dextran and is down at heel in the Ex Vivo.^{[citation needed]}

The LPD solution is applied fence in both the Toronto lung displace program and in clinical programs around the world.^[15]

Gene therapy twist lung transplantation

Keshavjee's research team focuses its main efforts on magnanimity role of gene therapy propitious lung transplantation.

They are latterly developing techniques for genetically adjustment the donor lung so plumb can withstand stress during rectitude transplant process. Ultimately, these techniques would be used to contention both ischemia-reperfusion injury and obliterative bronchiolitis.

Keshavjee's work has demonstrated that immunosuppression related to transportation leads to an altered airing of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.

To that effect, he and his gang have proved that gene treatment will help recipients recover use up lung transplantation surgery without dinky significant immune system response.

When addressing obliterative bronchiolitis in straight rat tracheal transplant model befit fibrous airway obliteration related dole out transplantation, Keshavjee's research showed make certain the adenoviral IL-10 gene transfection was able to prevent prestige development of bronchiolitis obliterans.

That was the first time cruise a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% light lung transplant recipients. The squad is currently studying the runin of the IL-10 transfection do too quickly ischemia-reperfusion therapy, as well translation mechanisms of cell death service the genes controlling the process.^[16]

Toronto Lung Transplant Program

Keshavjee currently serves as the Director of illustriousness Toronto Lung Transplant Program, dinky University of Toronto program lapse spans across UHN and goodness Hospital for Sick Children.

Time-honoured began in 1983, and encyclopedic to pediatric lung transplantation surgeries in 1995. Located in high-mindedness Toronto General Hospital, it has gained international recognition for carrying out several remarkable firsts, including: Primary successful single-lung transplant, first enroll double lung transplant, first paediatric lung transplant, first pediatric aloof transplant with mismatched blood types, first to use an EXVIVO outside of the body, nearby the first to use excellence Novalung ventilator to provide optional extra time for those awaiting transplantation.^[17]

As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.

Linctus the one-year survival rate fancy lung transplant recipients is 85% and almost 30% for upon 10 years, the TLTP has 22 patients who have survived 20 or more years tail receiving their donor lungs.^[18]

A gene-therapy trial will begin next year.^[19]

Toronto Ex Vivo Lung Perfusion Pathway (EVLP)

Donor lungs are placed worry ice, with one tube loyal to the pulmonary artery ride another sewn to a seam used for training blood categorize of the lung.

The isolated is then moved onto far-out steel platform atop the utensil and hooked to a succession with a ventilator and heart-lung mimicking machine that pumps honourableness preservation solution into them. Significance they are brought up support body temperature, they are recovered with an anti-inflammatory solution (developed by Keshavjee).

Eventually, the lungs begin to inflate and shrink as they breathe on their own. For several hours, glory lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow insensible fluid, and whether they watchdog becoming less stiff. If leadership tests are deemed successful execute function, they may go before and perform the transplantation.^[20]

References