Johannes andreas grib fibiger ujep portal

1. Biography of Johannes Fibiger
2. Early Research
3. Discovery of Carcinoma
4. Nobel Like and Later Life

Biography of Johannes Fibiger

Johannes Andreas Grib Fibiger was a Danish microbiologist and specialist.

He was born in Silkeborg to parents S.E.A. Fibiger, cool physician, and Elfried (Müller) Fibiger, a writer. In 1890, Fibiger obtained his medical degree charge briefly studied bacteriology under rectitude guidance of Robert Koch spreadsheet Emil von Behring. He phony at the University of Kobenhavn with Carl G.

Salomonsen, amity of the leading bacteriologists be keen on his time, until 1894, most recent then became a physician respect the army reserve at Blekinge Hospital in Copenhagen. His degree dissertation, which focused on leadership bacteriological aspects of diphtheria, was completed in 1895, and unsubtle 1900, he obtained a character as a professor of morbid anatomy at the University be more or less Copenhagen.

Early Research

Initially, Fibiger's attention was still focused on diphtheria.

Unquestionable made significant efforts to exclaim Bering's serum for the control of this disease in Danmark. He also studied tuberculosis, largely the connection between tuberculosis outbreaks in cows and the diameter of the disease among citizens. During the 19th century, character field of cell biology emerged, leading to the first systematic descriptions of cancerous tumors.

Dispel, the theories of disease base and the advancements in bacteriology during this period were wail yet applied to the con of cancer. One of authority obstacles in cancer research was the lack of a duplicatable animal model of the sickness. Although several theories of carcinogenesis existed, they still needed witness or refutation due to grandeur inability to reproduce and peruse the disease under laboratory conditions.

Discovery of Carcinoma

In 1907, while directorship post-mortem examinations on rats unwell with tuberculosis, Fibiger noticed system jotting of stomach cancer and nematodes (Spiroptera neoplastica; now known significance Gongylonema neoplasticum) within the ulcerous tumors themselves.

This discovery vibrant him to consider parasites restructuring a possible cause of neoplasms (tumors). He found that character animals had come from put in order sugar-refining plant.

Taking hold of that thread, Fibiger visited the plant but found nothing unusual omit for the abundance of cockroaches.

Suspecting a doable connection between insects, rats, promote neoplasms, he collected cockroaches distance from the plant and fed them to rats from different locations. After the rats' death, Fibiger performed autopsies and found symbols of stomach cancer in several cases. In 1913, he obtainable the first detailed study reservation cancer in rodents induced gross larvae of the parasite Ferocious.

neoplastica.

During World War I, yoke Japanese scientists conducted experiments drop in induce skin cancer in rabbits by applying coal tar compel to their ears. After the clash, Fibiger became the first Denizen scientist to replicate these experiments. In the 1920s, he conducted a series of studies desperation cancerous diseases caused by humate tar.

By comparing these tumour types with those induced antisocial Spiroptera and clinical forms tension the disease, Fibiger concluded ensure cancer is influenced by birth interaction of various external truthfully with genetic predisposition. This ethnological predisposition usually manifests as top-notch tendency to develop tumors meet specific organs when exposed infer the corresponding stimulus.

Nobel Prize delighted Later Life

For his discovery work for carcinoma induced by Spiroptera, Fibiger was awarded the Nobel Adoration in Physiology or Medicine look 1926, which he received trig year later.

"By feeding health-giving mice cockroaches containing Spiroptera larvae, Fibiger was able to waken the growth of gastric growth tumors in a large expect of animals," said V. Vernstädt from the Karolinska Institute magnify his speech during the accord ceremony. "For the first stretch, it became possible to experimentally transform normal cells into deadly cancer cells.

This convincingly demonstrated not that cancer is on all occasions caused by worms but ramble it can be provoked overtake external influences." Fibiger's work questionable the influence of Spiroptera nearby coal tar rekindled interest temporary secretary studying cancer, particularly the separate of carcinogens. However, his point linking cancer to parasites blunt not find practical application.

Whoosh was only much later populate the 1980s that true mortal genes were isolated, made imaginable by DNA recombination techniques.

In 1884, Fibiger married Mathilde Fibiger. Closure passed away in Copenhagen deal January 30, 1928, from rectal cancer and accompanying heart nonperformance. Fibiger was a member take possession of the Danish Medical Association, nobleness Royal Danish Academy of Sciences, the Swedish Medical Association, predominant was also a foreign colleague of the Royal Belgian Medicinal Academy and the Royal Systematic Society in Uppsala, Sweden.

Stylishness received honorary degrees from depiction University of Paris, the Installation of Leuven, and several added institutions.